I have, in my work, noticed that *Gastrofor will lessen the risk of histamine secretion of the stomach, which will decrease the risk of developing gastric ulcers, even when the horse still is given feed that causes an allergic reaction of the stomach. Now, the stomach lining can still be a little red and irritated due to the fact that the horse’s feeding schedule continuously causes an increased production of gastric acid but the Gastrofor will prevent the immunological reaction that leads to ulcers.
When the horse is given Gastrofor the stomach’s motor activity and emptying rate will increase and the load of the stomach nerves will be reduced. (The parasympathetic nervous system, via the vagus nerve takes part in the stimulation of the parietal cell to produce gastric acid, both directly acting on parietal cells and indirectly, through the stimulation of the secretion of histamine from enterochromaffine-like cells (ECL).)
Gastrofor will also normalize the immune defense reaction to feed and the histamine secretion* of the stomach will not be activated. Horses are extremely sensitive to histamine, which will start the allergic reaction that will lead to gastric ulcers.
When a horse is given Gastrofor continuously while given feed that causes allergic reactions, a gastroscopic examination on the horse in question can reveal a somewhat red and irritated mucus membrane but no allergic reaction. The absence of an allergic reaction will substantially reduce the risk of gastric ulcers. This scenario will happen when the gastric acid production, and the enzyme production, is high in order to break down alien allergy inducing substances from the feed.
In an allergic reaction to feed, a special type of antibody will be activated and signal to the mast cells to start produce large amounts of histamine. This will make the gastric acid producing glands of the stomach to increase the production substantially in order to be able to quickly break down the alien substances from the feed. This scenario will cause an allergic reaction of the stomach’s mucus membranes which can cause gastric ulcers.
Gastromin in North America and Gastrofor in Europe